Updated Phylogenetic Analysis of Polyomavirus-Host Co- Evolution

Phylogenetic analysis of the mammalian and avian polyomaviruses was performed using the most complete set of publicly available polyomavirus genome sequences to date, including the newly discovered MW polyomavirus. There is no evidence for host-switching between mammalian and avian polyomaviruses, but there is extensive evidence for host-switching among mammalian polyomaviruses. Comparative genomic analysis focuses on primate polyomaviruses, and two specific genomic alterations are shown for Merkel cell polyomavirus and Trichodysplasia spinulosa-associated polyomavirus that may indicate a mechanism for primate host-switching for these two human polyomaviruses.